Background:
@EN The host immune system normally functions to destroy neoplastic cells that continually
develop as a result of somatic mutations. However, patients with head and neck squamous
cell carcinoma have depressed cell-mediated immune function, which has recently been shown
to be most pronounced in the local and reginonal environment fo the primary tumor. Recent
studies suggest a local modulation of the host immune response to tumor by secreted
immunoregulatory factors such as cytokines, especially pro-inflammatory cytokines
(interleukin-1, interleukin-6, interleukin-8, interferons, and tumor necrosis factor).
@ES Materials and Methods:
@EN To assess the ability of head and neck squamous cell carcinoma to produce these
cytokines, initially, we have performed immunohistochemical staing for interleukin-6 and
tumor necrosis factor in 20 cases of laryngeal squamous cell carcinoma and 10 cases of
laryngeal nodule as a control group.
@ES Results:
@EN We detected interleukin-6 in 11 cases of laryngeal squamous cell carcinoma(55%) and
tumor necrosis factor in 11 cases of laryngeal squamous cell carcinoma(55%). All of 10
papillomas showed no expression of interleukin-6 and tumor necrosis factor expression and
clinical stage or pathologic grade.
@ES Conclusion:
@EN These results suggest that laryngeal squamous cell carcinoma may secrete cytokines
influencing the response of local immune cells. But future studies of the role of tumorderived
cytokines in the local immune response to tumor could be investigated, since cytokines may
directly or indirectly regulate tumor growth and metastasis.
|